Bioinformatics and Computational Biology

tree of life diagramOur researchers work on core computational biology-related problems, including genomics, proteomics, metagenomics, and phylogenomics. We develop novel techniques that combine ideas from mathematics, computer science, probability, statistics, and physics, and we help identify and formalize computational challenges in the biological domain, while experimentally validating novel hypotheses generated by our analyses.

We are developing algorithms with improved accuracy for large-scale and complex estimation problems in phylogenomics (genome-scale phylogeny estimation), multiple sequence alignment, and metagenomics. We are exploring gene regulation—developing advanced techniques to predict the diverse function of noncoding parts of DNA and to relate interspecies and interpersonal differences in DNA to differences in the organism’s form and function. We work broadly in the development of machine learning techniques for computational biology, with research spanning the areas of molecular and structural biology; networks and systems biology; and molecular mechanisms of human disease.

CS Faculty and Their Research Interests

Jiawei Han data mining for genomics and medical informatics
Jian Peng bioinformatics, protein function & structure, systems biology, machine learning and optimization
Saurabh Sinha bioinformatics, gene regulation, comparative genomics, sequence analysis
Tandy Warnow bioinformatics, multiple sequence alignment, phylogenomics, metagenomics, and historical linguistics
ChengXiang Zhai information retrieval, natural language processing for medical informatics

Bioinformatics and Computational Biology Research Efforts and Groups

Bioinformatics and Computational Biology Research News

Eight outstanding new faculty members are joining CS @ ILLINOIS during the next academic year.

CS @ ILLINOIS welcomes eight new faculty

September 21, 2017   Eight outstanding new faculty members are joining CS @ ILLINOIS during the next academic year. In total, thirty-six talented teachers and researchers have joined the department since 2013.
Dr. Ben Raphael

Distinguished Lecture Series: Dr. Ben Raphael

September 20, 2017   On September 25, Dr. Ben Raphael will present his research on cancer genomics.
Professors Aditya Parameswaran and Jian Peng have each received a prestigious CAREER Award from the National Science Foundation.

Parameswaran, Peng win NSF CAREER Awards

May 11, 2017   Assistant Professors Aditya Parameswaran and Jian Peng have each received a prestigious CAREER Award from the National Science Foundation to support their research.
Tandy Warnow

Warnow elected 2017 International Society for Computational Biology Fellow

February 13, 2017   Tandy Warnow is one of eight international scientists recognized for contributions to advancing the understanding of living systems through computation.
CS Professor Jiang Peng

Tool to map gene's ‘social network’ sheds light on function, interactions and drug efficacy

January 19, 2017   Jian Peng developed a tool to map a gene’s “social network” to help researchers better understand its function and interactions, offering insights into treatment.